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靶点信息11(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Membrane inhibitor of reactive lysis (CD59)
TARGTYPE
Clinical trial target
SYNONYMS
Protectin; Membrane attack complex inhibition factor; MSK21; MIRL; MIN3; MIN2; MIN1; MIC11; MEM43 antigen; MACinhibitory protein; MACIP; MACIF; MAC-inhibitory protein; MAC-IP; HRF20; HRF-20; CD59 glycoprotein; 20 kDa homologous restriction factor; 1F5 antigen
FUNCTION
Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Potent inhibitor of the complement membrane attack complex (MAC) action.
PDBSTRUC
5IMY; 5IMT; 4BIK; 2UX2; 2UWR
SEQUENCE
MGIQGGSVLFGLLLVLAVFCHSGHSLQCYNCPNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCNFNEQLENGGTSLSEKTVLLLVTPFLAAAWSLHP
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Membrane inhibitor of reactive lysis (CD59) |
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