TARGETID

T78393

FORMERID

TTDR01372

UNIPROID

MIF_HUMAN

TARGNAME

MIF messenger RNA (MIF mRNA)

GENENAME

MIF

TARGTYPE

Literature-reported target

SYNONYMS

Phenylpyruvate tautomerase (mRNA); MMIF (mRNA); L-dopachrome tautomerase (mRNA); L-dopachrome isomerase (mRNA); Glycosylation-inhibiting factor (mRNA); GLIF (mRNA); GIF (mRNA)

FUNCTION

Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. Pro-inflammatory cytokine.

PDBSTRUC

6FVH; 6FVE; 6CBH; 6CBG; 6CBF

BIOCLASS

mRNA target

ECNUMBER

EC 5.3.2.1

SEQUENCE

MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA

DRUGINFO

1-(2-chlorophenyl)-3-(pyridin-2-yl)thiourea

DRUGINFO

1-phenyl-3-(1,3,4-thiadiazol-2-yl)thiourea

DRUGINFO

2-(4-hydroxystyryl)quinolin-8-ol

DRUGINFO

3-(1H-pyrazol-3-yl)benzoic acid

DRUGINFO

3,3,3-tris(4-chlorophenyl)propanoic acid

DRUGINFO

3-acetyl-7-hydroxy-2H-chromen-2-one

DRUGINFO

3-benzyl-5-fluorobenzo[d]oxazol-2(3H)-one

DRUGINFO

3-benzyl-5-methylbenzo[d]oxazol-2(3H)-one