TARGETID

T78381

FORMERID

TTDI02296

UNIPROID

IFNL1_HUMAN

TARGNAME

Interleukin-29 (IL29)

GENENAME

IFNL1

TARGTYPE

Clinical trial target

SYNONYMS

ZCYTO21; Interleukin29; Interferon lambda1; Interferon lambda-1; IL-29; IFNlambda1; IFN-lambda-1; Cytokine Zcyto21

FUNCTION

Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. Cytokine with antiviral, antitumour and immunomodulatory activities.

PDBSTRUC

3OG6; 3OG4

BIOCLASS

Cytokine: interleukin

SEQUENCE

MAAAWTVVLVTLVLGLAVAGPVPTSKPTTTGKGCHIGRFKSLSPQELASFKKARDALEESLKLKNWSCSSPVFPGNWDLRLLQVRERPVALEAELALTLKVLEAAAGPALEDVLDQPLHTLHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKESAGCLEASVTFNLFRLLTRDLKYVADGNLCLRTSTHPEST

DRUGINFO

Peginterferon lambda-1a

DRUGINFO

PEG-Interferon lambda (IL-29)

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04630:Jak-STAT signaling pathway

WIKIPATH

WP2113:Type III interferon signaling