TARGETID

T78114

FORMERID

TTDI02050

UNIPROID

DAF_HUMAN

TARGNAME

Complement decay-accelerating factor (CD55)

GENENAME

CD55

TARGTYPE

Clinical trial target

SYNONYMS

DAF; Complement decayaccelerating factor; CR

FUNCTION

Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation.

PDBSTRUC

6ILK; 6ILJ; 5FOA; 3J24; 3IYP

SEQUENCE

MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSGHTCFTLTGLLGTLVTMGLLT

DRUGINFO

Coxsackievirus A21

DRUGINFO

Onyvax-105

DRUGINFO

PAT-SC1

KEGGPATH

hsa04610:Complement and coagulation cascades

KEGGPATH

hsa04640:Hematopoietic cell lineage

KEGGPATH

hsa05416:Viral myocarditis

WIKIPATH

WP1798:Complement cascade

WIKIPATH

WP1825:GPCR ligand binding

WIKIPATH

WP2806:Human Complement System

WIKIPATH

WP545:Complement Activation, Classical Pathway