TARGETID

T77350

FORMERID

TTDI03483

UNIPROID

PSB8_HUMAN

TARGNAME

Proteasome beta-8 (PS beta-8)

GENENAME

PSMB8

TARGTYPE

Clinical trial target

SYNONYMS

Y2; Really interesting new gene 10 protein; RING10; Proteasome subunit beta-5i; Proteasome subunit beta type-8; Proteasome component C13; PSMB5i; Multicatalytic endopeptidase complex subunit C13; Macropain subunit C13; Low molecular mass protein 7; LMP7

FUNCTION

The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

PDBSTRUC

6AVO; 5M2B; 5LTT; 5L5V; 5L5U

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.25.1

SEQUENCE

MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ

DRUGINFO

M3258

DRUGINFO

Dipeptide analog 1

DRUGINFO

Peptide analog 11

DRUGINFO

Peptide analog 13

DRUGINFO

Peptide analog 17

DRUGINFO

Peptide analog 19

DRUGINFO

Peptide analog 21

DRUGINFO

Peptide analog 23