TARGETID

T76914

FORMERID

TTDR00903

UNIPROID

KCNA3_HUMAN

TARGNAME

Voltage-gated potassium channel Kv1.3 (KCNA3)

GENENAME

KCNA3

TARGTYPE

Clinical trial target

SYNONYMS

Voltage-gated potassium channel subunit Kv1.3; Voltage-gated Kv1.3 K(+) channel; Voltage-gated K(+) channel Kv1.3; Potassium channel Kv1.3; KCNA3; HuKIII; HPCN3; HLK3; HGK5

FUNCTION

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

PDBSTRUC

4BGC

BIOCLASS

Voltage-gated ion channel

SEQUENCE

MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

DRUGINFO

Dalazatide

DRUGINFO

Debio-0824

DRUGINFO

UK-78282

DRUGINFO

[14C]TEA

DRUGINFO

[1-Benzyl-1H-quinolin-(4E)-ylidene]-hexyl-amine

DRUGINFO

1-Benzyl-7-chloro-4-hexyloxy-quinolinium

DRUGINFO

2-Methoxy-N-(3-methyl-2-phenyl-butyl)-benzamide

DRUGINFO

4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one

DRUGINFO

5-(4-Phenylbutoxy)psoralen