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靶点信息45(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Catechol-O-methyl-transferase (COMT)
TARGTYPE
Successful target
SYNONYMS
S-COMT; MB-COMT; Catechol-O-methyltransferase; COMT
FUNCTION
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
PDBSTRUC
5LSA; 4XUE; 4XUD; 4XUC; 4PYK
BIOCLASS
Methyltransferase
SEQUENCE
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
DRUGINFO
Entacapone+levodopa+carbidopa
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa00140 |
|
| hsa00350 |
|
| hsa01100 |
|
| hsa04728 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP704 |
|
| WP702 |
|
| WP697 |
|
| WP550 |
|
| WP2436 |
|
| WP1880 |
|
| WP1870 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Catechol-O-methyl-transferase (COMT) |
|