TARGETID

T76093

FORMERID

TTDNC00420

UNIPROID

HBEGF_HUMAN

TARGNAME

Proheparin-binding EGF-like growth factor (HBEGF)

GENENAME

HBEGF

TARGTYPE

Clinical trial target

SYNONYMS

Proheparinbinding EGFlike growth factor; Heparinbinding EGFlike growth factor; Heparin-binding EGF-like growth factor; HEGFL; HB-EGF; Diphtheria toxin receptor; DTS; DTR; DT-R

FUNCTION

Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4.

PDBSTRUC

2M8S; 1XDT

BIOCLASS

Growth factor

SEQUENCE

MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH

DRUGINFO

KHK-2866

DRUGINFO

U3-1565

KEGGPATH

hsa04012:ErbB signaling pathway

KEGGPATH

hsa04912:GnRH signaling pathway

KEGGPATH

hsa04915:Estrogen signaling pathway

KEGGPATH

hsa05120:Epithelial cell signaling in Helicobacter pylori infection

KEGGPATH

hsa05205:Proteoglycans in cancer

WIKIPATH

WP2653:PIP3 activates AKT signaling

WIKIPATH

WP2664:Gastrin-CREB signalling pathway via PKC and MAPK