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靶点信息23(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
FK506-binding protein 1A (FKBP1A)
TARGTYPE
Successful target
SYNONYMS
Rotamase; Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; Immunophillin FKBP; Immunophilin FKBP12; FKBP12; FKBP1; FKBP-1A; FKBP-12; FK-binding protein 12; Calstabin-1; 12 kDa FKBP; 12 kDa FK506-binding protein
FUNCTION
Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand.
PDBSTRUC
5I7Q; 5I7P; 4ODR; 4ODQ; 4ODP
BIOCLASS
Cis-trans-isomerase
SEQUENCE
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
DRUGINFO
4-Hydroxy-2-Butanone
DRUGINFO
Heptyl-Beta-D-Glucopyranoside
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| FK506-binding protein 1A (FKBP1A) |
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