TARGETID

T76024

FORMERID

TTDC00085

UNIPROID

C1S_HUMAN

TARGNAME

Complement C1s component (C1S)

GENENAME

C1S

TARGTYPE

Successful target

SYNONYMS

Complement component 1 subcomponent s; Complement C1s subcomponent; C1-esterase; C1 esterase

FUNCTION

C1r activates C1s so that it can, in turn, activate C2 and C4. C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.

PDBSTRUC

6F1H; 6F1C; 4LOT; 4LOS; 4LOR

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.21.42

SEQUENCE

MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED

DRUGINFO

Cinryze

DRUGINFO

Sutimlimab

DRUGINFO

ANX005

DRUGINFO

SHP616

DRUGINFO

TNT009

DRUGINFO

TS01

DRUGINFO

Fucose

DRUGINFO

PMID16460935C28