当前位置：药药网 / 数据中心 /靶点信息(本栏目收费,不能显示细节,电话13136136841)
靶点信息34(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
5-HT 2 receptor (5HT2R)
SYNONYMS
Serotonin receptor 2; 5-hydroxytryptamine receptor 2; 5-HT2 receptor
FUNCTION
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
DRUGINFO
Bis(olanzapine) pamoate monohydrate
DRUGINFO
Heterocyclic-tetracyclic tetrahydrofuran derivative 1
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04020 |
|
| hsa04080 |
|
| hsa04540 |
|
| hsa04726 |
|
| hsa04750 |
|