TARGETID

T75797

FORMERID

TTDS00169

UNIPROID

PF2R_HUMAN

TARGNAME

Prostaglandin F2-alpha receptor (PTGFR)

GENENAME

PTGFR

TARGTYPE

Successful target

SYNONYMS

Prostanoid FP receptor; PGF2-alpha receptor; PGF2 alpha receptor; PGF receptor; FP prostanoid receptor; FP prostaglandin receptor

FUNCTION

The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum. Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. Receptor for prostaglandin F2-alpha (PGF2-alpha).

BIOCLASS

GPCR rhodopsin

SEQUENCE

MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST

DRUGINFO

BOL-303259-X

DRUGINFO

Carboprost Tromethamine

DRUGINFO

Dinoprostone

DRUGINFO

Latanoprost

DRUGINFO

Tafluprost

DRUGINFO

Travoprost

DRUGINFO

LAROPIPRANT

DRUGINFO

PGF2ALPHA-IE

DRUGINFO

ONO-9054

DRUGINFO

PDC-41