靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T74456

FORMERID

TTDS00267

UNIPROID

AGTR1_HUMAN

TARGNAME

Angiotensin II receptor type-1 (AGTR1)

GENENAME

AGTR1

TARGTYPE

Successful target

SYNONYMS

Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; Angiotensin II receptor 1; Angiotensin 1 receptor; AT2R1B; AT2R1; AT1BR; AT1AR; AT1; AGTR1B; AGTR1A

FUNCTION

Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Receptor for angiotensin II.

PDBSTRUC

6DO1; 4ZUD; 4YAY; 1ZV0

BIOCLASS

GPCR rhodopsin

SEQUENCE

MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE

DRUGINFO

ANGIOTENSIN II

DRUGINFO

Azilsartan

DRUGINFO

Candesartan

DRUGINFO

Eprosartan

DRUGINFO

Forasartan

DRUGINFO

Irbesartan

DRUGINFO

Losartan

DRUGINFO

Micardis telmisartan

DRUGINFO

Olmesartan medoxomil

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04270	Vascular smooth muscle contraction
hsa04614	Renin-angiotensin system
hsa04924	Renin secretion
hsa05200	Pathways in cancer

目标的 Wiki 路径数据

标题	内容
WP554	ACE Inhibitor Pathway
WP455	GPCRs, Class A Rhodopsin-like
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP24	Peptide GPCRs
WP2328	Allograft Rejection
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T74456
UNIPROID	AGTR1_HUMAN
TARGNAME	Angiotensin II receptor type-1 (AGTR1)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Angiotensin II receptor type-1 (AGTR1)	MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE

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