TARGETID

T73482

FORMERID

TTDC00153

UNIPROID

OX1R_HUMAN

TARGNAME

Orexin receptor type 1 (HCRTR1)

GENENAME

HCRTR1

TARGTYPE

Clinical trial target

SYNONYMS

Ox1r; Ox1-R; Ox-1-R; Orexin-1 receptor; Hypocretin receptor type 1; HFGAN72 receptor; 7-transmembrane G-protein coupledneuropeptide receptor

FUNCTION

Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide.

PDBSTRUC

4ZJC; 4ZJ8

BIOCLASS

GPCR rhodopsin

SEQUENCE

MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP

DRUGINFO

JNJ-61393215

DRUGINFO

SB-649868

DRUGINFO

1,2-diamino cyclopentane-based derivative 1

DRUGINFO

1,2-diamino cyclopentane-based derivative 10

DRUGINFO

1,2-diamino cyclopentane-based derivative 11

DRUGINFO

1,2-diamino cyclopentane-based derivative 12

DRUGINFO

1,2-diamino cyclopentane-based derivative 13

DRUGINFO

1,2-diamino cyclopentane-based derivative 14

DRUGINFO

1,2-diamino cyclopentane-based derivative 15