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靶点信息24(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Tissue factor (F3)
TARGTYPE
Clinical trial target
SYNONYMS
Thromboplastin; TF; F3; Coagulation factor III; CD142 antigen
FUNCTION
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assemblyand propagation of the coagulation protease cascade.
PDBSTRUC
5W06; 4ZMA; 4Z6A; 4YLQ; 4M7L
SEQUENCE
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
DRUGINFO
D-Pro-Phe-Arg chloromethyl ketone
KEGGPATH
hsa04610:Complement and coagulation cascades
WIKIPATH
WP1818:Formation of Fibrin Clot (Clotting Cascade)
WIKIPATH
WP558:Complement and Coagulation Cascades
WHIZPATH
PW000562:Coagulation
REACPATH
R-HSA-140834:Extrinsic Pathway of Fibrin Clot Formation
NET_PATH
NetPath_16:IL4 Signaling Pathway
目标的蛋白质ID
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