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靶点信息35(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
CCR5 messenger RNA (CCR5 mRNA)
TARGTYPE
Successful target
SYNONYMS
HIV-1 fusion coreceptor (mRNA); HIV-1 fusion co-receptor (mRNA); Chemokine receptor CCR5 (mRNA); CMKBR5 (mRNA); CHEMR13 (mRNA); CD195 antigen (mRNA); CD195 (mRNA); CCR-5 (mRNA); CC-CKR-5 (mRNA); C-C chemokine receptor type 5 (mRNA); C-C CKR-5 (mRNA)
FUNCTION
May play a role in the control of granulocytic lineage proliferation or differentiation. Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
PDBSTRUC
6MET; 6MEO; 6FGP; 5YY4; 5YD5
SEQUENCE
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
DRUGINFO
DdRNAi therapy rHIV7-shl-TAR-CCR5RZ, stem cells
DRUGINFO
viral macrophage inflammatory protein-II
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04062:Chemokine signaling pathway
KEGGPATH
hsa04144:Endocytosis
KEGGPATH
hsa05145:Toxoplasmosis
KEGGPATH
hsa05203:Viral carcinogenesis
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04062 |
|
| hsa04144 |
|
| hsa05145 |
|
| hsa05203 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP69 |
|
| WP455 |
|
| WP2658 |
|
| WP24 |
|
| WP1825 |
|
| WP1824 |
|
| WP117 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| CCR5 messenger RNA (CCR5 mRNA) |
|