靶点信息33(本栏目收费,不能显示细节,电话13136136841)
靶点信息
标题
内容
相关药物
状态
TARGETID
T71390
FORMERID
TTDR01183
UNIPROID
S5A2_HUMAN
TARGNAME
Steroid 5-alpha-reductase 2 (SRD5A2)
GENENAME
SRD5A2
TARGTYPE
Successful target
SYNONYMS
Type 2 steroid 5alpha-reductase (5alpha-R); SRD5A2; SR type 2; 5-alpha reductase 2; 5 alpha-SR2
FUNCTION
Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
BIOCLASS
CH-CH donor oxidoreductase
ECNUMBER
EC 1.3.1.22
SEQUENCE
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
DRUGINFO
Finasteride
DRUGINFO
(3-fluoro-4-(4-phenoxybenzoyl)phenyl)acetic acid
DRUGINFO
(3-methyl-4-(4-phenoxybenzoyl)phenyl)acetic acid
DRUGINFO
(E)-3-(4-(4-phenoxybenzoyl)phenyl)acrylic acid
DRUGINFO
{4-[4-(4-bromophenoxy)benzoyl]phenyl}acetic acid
DRUGINFO
2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol
DRUGINFO
3-[4-(4-phenoxybenzoyl)phenyl]propanoic acid
DRUGINFO
4-(4-phenoxybenzoyl)benzoic acid
DRUGINFO
4-(4-phenoxybenzoyl)phenylacetic acid
目标的 KEGG 通路数据
标题内容
hsa00140
hsa05215
目标的 Wiki 路径数据
标题内容
目标的蛋白质ID
标题内容
TARGETID
UNIPROID
TARGNAME
TARGTYPE
目标的序列数据
标题内容
Steroid 5-alpha-reductase 2 (SRD5A2)
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