TARGETID

T71192

FORMERID

TTDS00183

UNIPROID

CLTR1_HUMAN

TARGNAME

Leukotriene CysLT1 receptor (CYSLTR1)

GENENAME

CYSLTR1

TARGTYPE

Successful target

SYNONYMS

Leukotriene D4-receptor; LTD4 receptor; HMTMF81; HG55; G-protein coupled receptor HG55; Cysteinyl leukotriene receptor 1; Cysteinyl leukotriene D4 receptor; CysLTR1; CYSLT1

FUNCTION

Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV

DRUGINFO

Cinalukast

DRUGINFO

Montelukast

DRUGINFO

Pranlukast

DRUGINFO

Zafirlukast

DRUGINFO

Claritin/Singulair

DRUGINFO

BAY-X-7195

DRUGINFO

Iralukast

DRUGINFO

KP-496

DRUGINFO

LM-1507.NA

DRUGINFO

Masilukast