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靶点信息27(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Dipeptidyl peptidase I (CTSC)
TARGTYPE
Clinical trial target
SYNONYMS
Dipeptidyl transferase; Dipeptidyl peptidase 1; DPPI; DPP-I; Cysteine protease dipeptidyl peptidase I; Cathepsin J; Cathepsin C; CPPI
FUNCTION
Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. Thiol protease.
PDBSTRUC
4OEM; 4OEL; 4CDF; 4CDE; 4CDD
SEQUENCE
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
DRUGINFO
(S)-2-amino-N-(1-cyano-2-phenylethyl)acetamide
KEGGPATH
hsa04142:Lysosome
WIKIPATH
WP2002:miR-targeted genes in epithelium - TarBase
WIKIPATH
WP2003:miR-targeted genes in leukocytes - TarBase
WIKIPATH
WP2004:miR-targeted genes in lymphocytes - TarBase
目标的 Wiki 路径数据
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目标的蛋白质ID
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目标的序列数据
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| Dipeptidyl peptidase I (CTSC) |
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