靶点信息23(本栏目收费,不能显示细节,电话13136136841)
靶点信息
标题
内容
相关药物
状态
TARGETID
T70101
FORMERID
TTDR00956
UNIPROID
PYRG1_HUMAN
TARGNAME
CTP synthase (CTPS1)
GENENAME
CTPS1
TARGTYPE
Clinical trial target
SYNONYMS
Uridine triphosphate aminase; UTP:ammonia ligase (ADP-forming); UTP--ammonia ligase; Cytidine triphosphate synthetase; Cytidine 5'-triphosphate synthetase; CTPS1; CTP synthetase
FUNCTION
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP- dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
PDBSTRUC
5U03; 2VO1
BIOCLASS
Carbon-nitrogen ligase
ECNUMBER
EC 6.3.4.2
SEQUENCE
MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD
DRUGINFO
Cyclopentenylcytosine
DRUGINFO
Acivicin
DRUGINFO
2-Methyl-2,4-Pentanediol
DRUGINFO
Carbodine
DRUGINFO
Cyclopentylcytosine
DRUGINFO
Cylopentenyl cytosine
KEGGPATH
hsa00240:Pyrimidine metabolism
KEGGPATH
hsa01100:Metabolic pathways
目标的 KEGG 通路数据
标题内容
hsa00240
hsa01100
目标的 Wiki 路径数据
标题内容
WP1851
目标的蛋白质ID
标题内容
TARGETID
UNIPROID
TARGNAME
TARGTYPE
目标的序列数据
标题内容
CTP synthase (CTPS1)
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