TARGETID

T70067

FORMERID

TTDC00266

UNIPROID

TR10B_HUMAN

TARGNAME

TRAIL receptor 2 (TRAIL-R2)

GENENAME

TNFRSF10B

TARGTYPE

Clinical trial target

SYNONYMS

ZTNFR9; UNQ160/PRO186; Tumor necrosis factor receptor superfamily member 10B; TRICK2; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; KILLER; Death receptor 5; DR5; CD262

FUNCTION

The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. Receptor for the cytotoxic ligand TNFSF10/TRAIL.

PDBSTRUC

6NHY; 6NHW; 4OD2; 4N90; 4I9X

BIOCLASS

Cytokine receptor

SEQUENCE

MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS

DRUGINFO

Conatumumab

DRUGINFO

Lexatumumab

DRUGINFO

Anti-DR5 cells

DRUGINFO

BI 905711

DRUGINFO

DS-8273

DRUGINFO

GEN1029

DRUGINFO

IGM-8444

DRUGINFO

INBRX-109

DRUGINFO

RhApo2L/TRAIL