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靶点信息

标题

内容

相关药物

状态

TARGETID

T69146

FORMERID

TTDR00084

UNIPROID

UCP3_HUMAN

TARGNAME

Mitochondrial uncoupling protein 3 (UCP3)

GENENAME

UCP3

TARGTYPE

Clinical trial target

SYNONYMS

UCP 3; Solute carrier family 25 member 9; SLC25A9

FUNCTION

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.

BIOCLASS

Mitochondrial carrier

SEQUENCE

MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRALMKVQMLRESPF

DRUGINFO

D07WHS

CL-316,243

Phase 2

WIKIPATH

WP111:Electron Transport Chain

WIKIPATH

WP1902:Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

WIKIPATH

WP410:Diurnally Regulated Genes with Circadian Orthologs

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容
WP410	Diurnally Regulated Genes with Circadian Orthologs
WP1902	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
WP111	Electron Transport Chain

目标的蛋白质ID

标题	内容
TARGETID	T69146
UNIPROID	UCP3_HUMAN
TARGNAME	Mitochondrial uncoupling protein 3 (UCP3)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Mitochondrial uncoupling protein 3 (UCP3)	MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRALMKVQMLRESPF

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