靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T69085

FORMERID

TTDC00119

UNIPROID

JUN_HUMAN

TARGNAME

Transcription factor AP-1 (JUN)

GENENAME

JUN

TARGTYPE

Discontinued target

SYNONYMS

V-jun avian sarcoma virus 17 oncogene homolog; Proto-oncogene c-jun; P39; C-jun proto-oncogene; Activator protein-1; Activator protein 1; AP1; AP-1 transcription factor

FUNCTION

Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells. Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

PDBSTRUC

5T01; 5FV8; 1T2K; 1S9K; 1JNM

BIOCLASS

Basic leucine zipper bZIP

SEQUENCE

MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF

DRUGINFO

D02LCL

T-5224

Discontinued in Phase 2

DRUGINFO

PNRI-299

DRUGINFO

TAM-67

DRUGINFO

TWS-119

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04012:ErbB signaling pathway

KEGGPATH

hsa04024:cAMP signaling pathway

KEGGPATH

hsa04310:Wnt signaling pathway

KEGGPATH

hsa04380:Osteoclast differentiation

目标的 KEGG 通路数据

标题	内容
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04024	cAMP signaling pathway
hsa04310	Wnt signaling pathway
hsa04380	Osteoclast differentiation
hsa04510	Focal adhesion
hsa04620	Toll-like receptor signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04668	TNF signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04912	GnRH signaling pathway
hsa04915	Estrogen signaling pathway
hsa04921	Oxytocin signaling pathway
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa05030	Cocaine addiction
hsa05031	Amphetamine addiction
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05132	Salmonella infection
hsa05133	Pertussis
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05161	Hepatitis B
hsa05164	Influenza A
hsa05166	HTLV-I infection
hsa05168	Herpes simplex infection
hsa05169	Epstein-Barr virus infection
hsa05200	Pathways in cancer
hsa05203	Viral carcinogenesis
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05231	Choline metabolism in cancer
hsa05321	Inflammatory bowel disease (IBD)
hsa05323	Rheumatoid arthritis

目标的 Wiki 路径数据

标题	内容
WP75	Toll-like receptor signaling pathway
WP712	Estrogen signaling pathway
WP710	DNA Damage Response (only ATM dependent)
WP706	SIDS Susceptibility Pathways
WP69	TCR Signaling Pathway
WP673	ErbB Signaling Pathway
WP615	Senescence and Autophagy in Cancer
WP560	TGF Beta Signaling Pathway
WP49	IL-2 Signaling Pathway
WP481	Insulin Signaling
WP437	EGF/EGFR Signaling Pathway
WP428	Wnt Signaling Pathway
WP422	MAPK Cascade
WP399	Wnt Signaling Pathway and Pluripotency
WP382	MAPK Signaling Pathway
WP366	TGF beta Signaling Pathway
WP3286	Copper homeostasis
WP314	FAS pathway and Stress induction of HSP regulation
WP313	Signaling of Hepatocyte Growth Factor Receptor
WP306	Focal Adhesion
WP289	Myometrial Relaxation and Contraction Pathways
WP2882	Nuclear Receptors Meta-Pathway
WP2881	Estrogen Receptor Pathway
WP2873	Aryl Hydrocarbon Receptor Pathway
WP286	IL-3 Signaling Pathway
WP2840	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WP28	Selenium Metabolism and Selenoproteins
WP2786	Pre-NOTCH Expression and Processing
WP2759	Fc epsilon receptor (FCERI) signaling
WP2571	Polycystic Kidney Disease Pathway
WP254	Apoptosis
WP2526	PDGF Pathway
WP2516	ATM Signaling Pathway
WP2435	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
WP2380	BDNF signaling pathway
WP2377	Integrated Pancreatic Cancer Pathway
WP2324	AGE/RAGE pathway
WP231	TNF alpha Signaling Pathway
WP23	B Cell Receptor Signaling Pathway
WP2263	Prostate Cancer
WP2100	Arylhydrocarbon receptor (AhR) signaling pathway
WP2036	TWEAK Signaling Pathway
WP2032	TSH signaling pathway
WP2018	RANKL/RANK Signaling Pathway
WP1984	Integrated Breast Cancer Pathway
WP195	IL-1 signaling pathway
WP1845	MAPK targets/ Nuclear events mediated by MAP kinases
WP1772	Apoptosis Modulation and Signaling
WP1528	Physiological and Pathological Hypertrophy of the Heart
WP1449	Regulation of toll-like receptor signaling pathway
WP138	Androgen receptor signaling pathway
WP127	IL-5 Signaling Pathway

目标的蛋白质ID

标题	内容
TARGETID	T69085
UNIPROID	JUN_HUMAN
TARGNAME	Transcription factor AP-1 (JUN)
TARGTYPE	Discontinued target

目标的序列数据

标题	内容
Transcription factor AP-1 (JUN)	MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF

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