靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T68334

FORMERID

TTDS00438

UNIPROID

FSHR_HUMAN

TARGNAME

Follicle-stimulating hormone receptor (FSHR)

GENENAME

FSHR

TARGTYPE

Successful target

SYNONYMS

LGR1; Follitropin receptor; FSH-R

FUNCTION

G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.

PDBSTRUC

4MQW; 4AY9; 1XWD; 1XUN

BIOCLASS

GPCR rhodopsin

SEQUENCE

MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN

DRUGINFO

Follitropin beta

DRUGINFO

Menotropins

DRUGINFO

Urofollitropin

DRUGINFO

Suramin

DRUGINFO

FSHR NAM

DRUGINFO

Long-acting FSH conjugate

DRUGINFO

PRX-111

DRUGINFO

Recombinant follicle stimulating hormone

Investigative

KEGGPATH

hsa04024:cAMP signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa04024	cAMP signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04913	Ovarian steroidogenesis

目标的 Wiki 路径数据

标题	内容
WP455	GPCRs, Class A Rhodopsin-like
WP34	Ovarian Infertility Genes
WP24	Peptide GPCRs
WP2035	FSH signaling pathway
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling
WP117	GPCRs, Other

目标的蛋白质ID

标题	内容
TARGETID	T68334
UNIPROID	FSHR_HUMAN
TARGNAME	Follicle-stimulating hormone receptor (FSHR)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Follicle-stimulating hormone receptor (FSHR)	MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN

标题

内容

Follicle-stimulating hormone receptor (FSHR)

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