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靶点信息

标题

内容

相关药物

状态

TARGETID

T67942

FORMERID

TTDR00871

UNIPROID

METB_ECOLI

TARGNAME

Bacterial Cystathionine gamma-synthase (Bact metB)

GENENAME

Bact metB

TARGTYPE

Literature-reported target

SYNONYMS

metB; O-succinylhomoserine (Thiol)-lyase; CGS

FUNCTION

Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia.

PDBSTRUC

1CS1

BIOCLASS

Alkyl aryl transferase

ECNUMBER

EC 2.5.1.48

SEQUENCE

MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANKG

DRUGINFO

D03ESO

GW-3333

Preclinical

DRUGINFO

D0I5PZ

N'-Pyridoxyl-Lysine-5'-Monophosphate

Investigative

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T67942
UNIPROID	METB_ECOLI
TARGNAME	Bacterial Cystathionine gamma-synthase (Bact metB)
TARGTYPE	Research target

目标的序列数据

标题	内容
Bacterial Cystathionine gamma-synthase (Bact metB)	MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANKG

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