靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T67684

FORMERID

TTDS00004

UNIPROID

ACM3_HUMAN

TARGNAME

Muscarinic acetylcholine receptor M3 (CHRM3)

GENENAME

CHRM3

TARGTYPE

Successful target

SYNONYMS

M3 receptor; CHRM3

FUNCTION

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

PDBSTRUC

2CSA

BIOCLASS

GPCR rhodopsin

SEQUENCE

MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL

DRUGINFO

ACECLIDINE

DRUGINFO

Cevimeline

DRUGINFO

Darifenacin

DRUGINFO

Ipratropium

DRUGINFO

LAS-34273

DRUGINFO

Methacholine Chloride

Approved

DRUGINFO

D04LHJ

Methscopolamine Bromide

DRUGINFO

Methylscopolamine

DRUGINFO

SMT-D002

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04725	Cholinergic synapse
hsa04810	Regulation of actin cytoskeleton
hsa04911	Insulin secretion
hsa04970	Salivary secretion
hsa04971	Gastric acid secretion
hsa04972	Pancreatic secretion

目标的 Wiki 路径数据

标题	内容
WP58	Monoamine GPCRs
WP536	Calcium Regulation in the Cardiac Cell
WP51	Regulation of Actin Cytoskeleton
WP455	GPCRs, Class A Rhodopsin-like
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP1831	Integration of energy metabolism
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling
WP117	GPCRs, Other

目标的蛋白质ID

标题	内容
TARGETID	T67684
UNIPROID	ACM3_HUMAN
TARGNAME	Muscarinic acetylcholine receptor M3 (CHRM3)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Muscarinic acetylcholine receptor M3 (CHRM3)	MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL

标题

内容

Muscarinic acetylcholine receptor M3 (CHRM3)

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