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靶点信息25(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Charybdotoxin receptor beta-4 (BKbeta4)
TARGTYPE
Clinical trial target
SYNONYMS
KCNMB4; Calcium activated potassium KCNMA1 (maxiK) channel
FUNCTION
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
SEQUENCE
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
KEGGPATH
hsa04022:cGMP-PKG signaling pathway
KEGGPATH
hsa04270:Vascular smooth muscle contraction
KEGGPATH
hsa04911:Insulin secretion
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04022 |
|
| hsa04270 |
|
| hsa04911 |
|
| hsa04970 |
|
| hsa04972 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Charybdotoxin receptor beta-4 (BKbeta4) |
|