TARGETID

T65019

FORMERID

TTDC00042

UNIPROID

MMP14_HUMAN

TARGNAME

Matrix metalloproteinase-14 (MMP-14)

GENENAME

MMP14

TARGTYPE

Clinical trial target

SYNONYMS

Membrane-type-1 matrix metalloproteinase; Membrane-type matrix metalloproteinase 1; MTMMP1; MT1MMP; MT1-MMP; MT-MMP 1; MMP-X1

FUNCTION

Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Endopeptidase that degrades various components of the extracellular matrix such as collagen.

PDBSTRUC

6CM1; 6CLZ; 5H0U; 4QXU; 4P3D

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.24.80

SEQUENCE

MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV

DRUGINFO

Epigallocatechin gallate

DRUGINFO

BT1718

DRUGINFO

GM6001

DRUGINFO

[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid

DRUGINFO

2-(4-bromophenylsulfonamido)-N-hydroxyacetamide

DRUGINFO

2-(biphenyl-4-ylsulfonamido)-N-hydroxyacetamide

DRUGINFO

2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide

DRUGINFO

DX-2400