TARGETID

T64987

FORMERID

TTDR00919

UNIPROID

LMP1_EBVG

TARGNAME

Epstein-Barr virus Latent membrane protein 1 (EBV LMP1)

GENENAME

EBV LMP1

TARGTYPE

Clinical trial target

SYNONYMS

Protein p63; P63; Latent membrane protein 1; LMP1; LMP-1; BNLF1

FUNCTION

Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation.

SEQUENCE

MERDLERGPPGPPRPPLGPPLSSSIGLALLLLLLALLFWLYIVLSNWTGGALLVLYSFALMLIIIILIIFIFRRDLLCPLGGLGLLLLMVTLLLIALWNLHGQALYLGIVLFIFGCLLVLGLWIYFLEILWRLGATIWQLLAFILAFFLAIILLIIALYLQQNWWTLLVDLLWLLLFMAILIWMYFHGPRHTDEHHHDDSLPHPQQATDDSSHESDSNSNEGRHHLLVSGAGDGPPLCSQNLGAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGNTDDNGPQDPDNTDDNGPHDPLPHNPSDSAGNDGGPPNLTEEVENKGGDRGPPSMTDGGGGDPHLPTLLLGTSGSGGDDDDPHGPVQLSYYD

DRUGINFO

LMP1-CAR-T cells

DRUGINFO

LMP-1/LMP-2 CTLs

DRUGINFO

Ad5f35-LMPd1-2-transduced autologous dendritic cells