TARGETID

T64591

FORMERID

TTDS00399

UNIPROID

5HT3A_HUMAN

TARGNAME

5-HT 3A receptor (HTR3A)

GENENAME

HTR3A

TARGTYPE

Successful target

SYNONYMS

Serotonin-gated ion channel receptor; Serotonin receptor 3A; HTR3; 5HT3R; 5-hydroxytryptamine receptor 3A; 5-HT3RA; 5-HT3A; 5-HT3-A; 5-HT 3A

FUNCTION

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA

DRUGINFO

Alosetron

DRUGINFO

Dolasetron

DRUGINFO

Levetiracetam

DRUGINFO

Palonosetron

DRUGINFO

Palonosetron + fosnetupitant

DRUGINFO

Procaine

DRUGINFO

Tropisetron

DRUGINFO

Cilansetron

DRUGINFO

BEMESETRON

DRUGINFO

Norcisapride