TARGETID

T64567

FORMERID

TTDR00211

UNIPROID

CAH9_HUMAN

TARGNAME

Carbonic anhydrase IX (CA-IX)

GENENAME

CA9

TARGTYPE

Clinical trial target

SYNONYMS

Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX

FUNCTION

Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Reversible hydration of carbon dioxide.

PDBSTRUC

6G9U; 6G98; 6FE2; 6FE1; 6FE0

BIOCLASS

Alpha-carbonic anhydrase

ECNUMBER

EC 4.2.1.1

SEQUENCE

MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA

DRUGINFO

Curcumin

DRUGINFO

PARABEN

DRUGINFO

PHENOL

DRUGINFO

Coumate

DRUGINFO

Girentuximab I-124

DRUGINFO

INDISULAM

DRUGINFO

90Y-cG250

DRUGINFO

BAY 79-4620