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靶点信息138(本栏目收费,不能显示细节,电话15274084725)
靶点信息
TARGNAME
Histone deacetylase 4 (HDAC4)
TARGTYPE
Clinical trial target
FUNCTION
Gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
PDBSTRUC
6FYZ; 5ZOP; 5ZOO; 5A2S; 4CBY
BIOCLASS
Carbon-nitrogen hydrolase
SEQUENCE
MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL
DRUGINFO
PMID29671355-Compound-12
DRUGINFO
PMID29671355-Compound-21
DRUGINFO
PMID29671355-Compound-23
DRUGINFO
PMID29671355-Compound-25
DRUGINFO
PMID29671355-Compound-31
DRUGINFO
PMID29671355-Compound-43
DRUGINFO
PMID29671355-Compound-45a
DRUGINFO
PMID29671355-Compound-47a
目标的 KEGG 通路数据
标题 | 内容 |
hsa05034 |
|
hsa05169 |
|
hsa05203 |
|
hsa05206 |
|
目标的 Wiki 路径数据
标题 | 内容 |
WP2064 |
|
WP2005 |
|
WP2004 |
|
WP2002 |
|
WP1992 |
|
WP179 |
|
WP1544 |
|
WP474 |
|
WP2795 |
|
目标的蛋白质ID
标题 | 内容 |
TARGETID |
|
UNIPROID |
|
TARGNAME |
|
TARGTYPE |
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目标的序列数据
标题 | 内容 |
Histone deacetylase 4 (HDAC4) |
|