TARGETID

T63083

FORMERID

TTDR00922

UNIPROID

RAD51_HUMAN

TARGNAME

DNA repair protein RAD51 homolog 1 (RAD51)

GENENAME

RAD51

TARGTYPE

Clinical trial target

SYNONYMS

hRAD51; RECA; RAD51A; RAD51 homolog A; HsRAD51

FUNCTION

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair.

PDBSTRUC

5NWL; 5NP7; 5JZC; 5H1C; 5H1B

SEQUENCE

MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD

DRUGINFO

CYT-0851

DRUGINFO

AMP-PNP

KEGGPATH

hsa03440:Homologous recombination

KEGGPATH

hsa03460:Fanconi anemia pathway

KEGGPATH

hsa05200:Pathways in cancer

KEGGPATH

hsa05212:Pancreatic cancer

WIKIPATH

WP1530:miRNA Regulation of DNA Damage Response

WIKIPATH

WP1807:Double-Strand Break Repair

WIKIPATH

WP186:Homologous recombination

WIKIPATH

WP1984:Integrated Breast Cancer Pathway