TARGETID

T59679

FORMERID

TTDS00107

UNIPROID

5HT4R_HUMAN

TARGNAME

5-HT 4 receptor (HTR4)

GENENAME

HTR4

TARGTYPE

Successful target

SYNONYMS

Serotonin receptor 4; 5-hydroxytryptamine receptor 4; 5-HT4 receptor; 5-HT4; 5-HT-4

FUNCTION

The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.

PDBSTRUC

5EM9

BIOCLASS

GPCR rhodopsin

SEQUENCE

MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT

DRUGINFO

Cisapride

DRUGINFO

HTF 919

DRUGINFO

R0-93877

DRUGINFO

Tegaserod

DRUGINFO

Mosapride

DRUGINFO

Renzapride

DRUGINFO

DSP-6952

DRUGINFO

Lintopride

DRUGINFO

PF-885706