TARGETID

T59631

FORMERID

TTDNC00489

UNIPROID

PDCD1_HUMAN

TARGNAME

Programmed cell death protein 1 (PD-1)

GENENAME

PDCD1

TARGTYPE

Successful target

SYNONYMS

hPD1; hPD-1; Protein PD1; Protein PD-1; PD1; CD279

FUNCTION

Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self.

PDBSTRUC

5WT9; 5JXE; 5IUS; 5GGS; 5GGR

BIOCLASS

Immunoglobulin

SEQUENCE

MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL

DRUGINFO

Cemiplimab

DRUGINFO

Dostarlimab

DRUGINFO

MK-3475

DRUGINFO

Nivolumab

DRUGINFO

Pembrolizumab

DRUGINFO

Sintilimab

DRUGINFO

Tislelizumab

DRUGINFO

BGB-A317

DRUGINFO

IBI-308