靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T58589

FORMERID

TTDR00405

UNIPROID

BKRB1_HUMAN

TARGNAME

B1 bradykinin receptor (BDKRB1)

GENENAME

BDKRB1

TARGTYPE

Clinical trial target

SYNONYMS

BRADYB1; BK-1 receptor; B1R

FUNCTION

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN

DRUGINFO

Safotibant

DRUGINFO

SSR-240612

DRUGINFO

BI 113823

DRUGINFO

Ac-Lys-[Leu(8)]-des-Arg(9)-BK

Investigative

DRUGINFO

D04KWH

Des-Arg(9)-[Leu(8)]-BK

DRUGINFO

Des-Arg10-Kallidin

DRUGINFO

Des-Arg10-Leu9-Kallidin

Investigative

DRUGINFO

D00FAE

H-DArg-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH(JMV1638)

Investigative

DRUGINFO

D0C3KW

H-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH(JMV1645)

Investigative

DRUGINFO

D02DGP

H-Lys-Arg-Pro-Hyp-Gly-Thi-Ser-D-BT-OH(JMV1669)

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04610	Complement and coagulation cascades
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer

目标的 Wiki 路径数据

标题	内容
WP558	Complement and Coagulation Cascades
WP554	ACE Inhibitor Pathway
WP51	Regulation of Actin Cytoskeleton
WP455	GPCRs, Class A Rhodopsin-like
WP2877	Vitamin D Receptor Pathway
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP24	Peptide GPCRs
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T58589
UNIPROID	BKRB1_HUMAN
TARGNAME	B1 bradykinin receptor (BDKRB1)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
B1 bradykinin receptor (BDKRB1)	MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN

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