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靶点信息22(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Interleukin-11 (IL11)
TARGTYPE
Clinical trial target
SYNONYMS
Oprelvekin; IL-11; Adipogenesis inhibitory factor; AGIF
FUNCTION
Promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
BIOCLASS
Cytokine: interleukin
SEQUENCE
MNCVCRLVLVVLSLWPDTAVAPGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04630:Jak-STAT signaling pathway
KEGGPATH
hsa04640:Hematopoietic cell lineage
KEGGPATH
hsa05323:Rheumatoid arthritis
WIKIPATH
WP2332:Interleukin-11 Signaling Pathway
WIKIPATH
WP2377:Integrated Pancreatic Cancer Pathway
WIKIPATH
WP2848:Differentiation Pathway
WIKIPATH
WP530:Cytokines and Inflammatory Response
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04630 |
|
| hsa04640 |
|
| hsa05323 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP530 |
|
| WP2848 |
|
| WP2377 |
|
| WP2332 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Interleukin-11 (IL11) |
|