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靶点信息20(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Ubiquitin thioesterase L1 (UCHL1)
TARGTYPE
Preclinical target
SYNONYMS
Ubiquitin thiolesterase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin carboxy-terminal hydrolase L1; UCH-L1; PGP9.5; PGP 9.5; Neuron cytoplasmic protein 9.5
FUNCTION
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
PDBSTRUC
4JKJ; 4DM9; 3KW5; 3KVF; 3IRT
SEQUENCE
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
WIKIPATH
WP183:Proteasome Degradation
WIKIPATH
WP2371:Parkinsons Disease Pathway
NET_PATH
NetPath_7:TGF_beta_Receptor Signaling Pathway
INTEPATH
alphasynuclein_pathway:Alpha-synuclein signaling
PANTPATH
P00049:Parkinson disease
目标的蛋白质ID
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| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Ubiquitin thioesterase L1 (UCHL1) |
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