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靶点信息34(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Delta-like protein 4 (DLL4)
TARGTYPE
Clinical trial target
SYNONYMS
UNQ1895/PRO4341; Drosophila Delta homolog 4; Deltalike protein 4; Delta4
FUNCTION
Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. Involved in the Notch signaling pathway as Notch ligand.
SEQUENCE
MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV
KEGGPATH
hsa04330:Notch signaling pathway
WIKIPATH
WP2064:Neural Crest Differentiation
WIKIPATH
WP268:Notch Signaling Pathway
WIKIPATH
WP2718:Signaling by NOTCH2
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP61 |
|
| WP2722 |
|
| WP2721 |
|
| WP2720 |
|
| WP2718 |
|
| WP268 |
|
| WP2064 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Delta-like protein 4 (DLL4) |
|