TARGETID

T54582

FORMERID

TTDI02132

UNIPROID

NAMPT_HUMAN

TARGNAME

Nicotinamide phosphoribosyltransferase (NAMPT)

GENENAME

NAMPT

TARGTYPE

Clinical trial target

SYNONYMS

Visfatin; PreBcell colonyenhancing factor 1; PreB cellenhancing factor; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; PBEF1; PBEF; Nampt; NAmPRTase

FUNCTION

It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD.

PDBSTRUC

6B76; 6B75; 6AZJ; 6ATB; 6.00E+68

BIOCLASS

Glycosyltransferases

ECNUMBER

EC 2.4.2.12

SEQUENCE

MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH

DRUGINFO

Daporinad

DRUGINFO

CHS-828

DRUGINFO

GMX1777

DRUGINFO

OT-82

KEGGPATH

hsa00760:Nicotinate and nicotinamide metabolism

KEGGPATH

hsa01100:Metabolic pathways

WIKIPATH

WP1797:Circadian Clock

WIKIPATH

WP1857:Metabolism of water-soluble vitamins and cofactors