靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T54156

FORMERID

TTDC00076

UNIPROID

MMP9_HUMAN

TARGNAME

Matrix metalloproteinase-9 (MMP-9)

GENENAME

MMP9

TARGTYPE

Clinical trial target

SYNONYMS

Matrix metalloproteinase 9; GELB; CLG4B; 92 kDa type IV collagenase; 92 kDa gelatinase

FUNCTION

Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration.

PDBSTRUC

6ESM; 5UE4; 5UE3; 5TH9; 5TH6

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.24.35

SEQUENCE

MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED

DRUGINFO

Andecaliximab

DRUGINFO

Curcumin

DRUGINFO

DP-b99

DRUGINFO

GS-5745

DRUGINFO

BLZ-100

DRUGINFO

Neovastat

DRUGINFO

PMID29130358-Compound-Figure13(4)

Patented

DRUGINFO

D09ATD

PMID29130358-Compound-Figure17(10)

Patented

目标的 KEGG 通路数据

标题	内容
hsa04668	TNF signaling pathway
hsa04670	Leukocyte transendothelial migration
hsa04915	Estrogen signaling pathway
hsa05161	Hepatitis B
hsa05200	Pathways in cancer
hsa05202	Transcriptional misregulation in cancer
hsa05205	Proteoglycans in cancer
hsa05206	MicroRNAs in cancer
hsa05219	Bladder cancer

目标的 Wiki 路径数据

标题	内容
WP474	Endochondral Ossification
WP2865	IL1 and megakaryotyces in obesity
WP2815	Mammary gland development pathway - Involution (Stage 4 of 4)
WP2769	Activation of Matrix Metalloproteinases
WP2708	Degradation of collagen
WP2431	Spinal Cord Injury
WP2324	AGE/RAGE pathway
WP2036	TWEAK Signaling Pathway
WP1539	Angiogenesis
WP1434	Osteopontin Signaling
WP129	Matrix Metalloproteinases

目标的蛋白质ID

标题	内容
TARGETID	T54156
UNIPROID	MMP9_HUMAN
TARGNAME	Matrix metalloproteinase-9 (MMP-9)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Matrix metalloproteinase-9 (MMP-9)	MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED

标题

内容

Matrix metalloproteinase-9 (MMP-9)

最新招商产品更多>>