TARGETID

T53748

FORMERID

TTDS00235

UNIPROID

Q965D5_PLAFA

TARGNAME

Plasmodium Enoyl-ACP reductase (Malaria fabI)

GENENAME

Malaria fabI

TARGTYPE

Successful target

SYNONYMS

fabI; NADH-dependent enoyl-ACP reductase; Enoyl-acyl-carrier protein reductase; Enoyl-acyl carrier reductase; Enoyl-acyl carrier protein reductase; Enoyl-ACP reductase FabI

FUNCTION

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.

BIOCLASS

CH-CH donor oxidoreductase

ECNUMBER

EC 1.3.1.9

SEQUENCE

MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNKMKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRNENE

DRUGINFO

Triclosan

DRUGINFO

Epigallocatechin gallate

DRUGINFO

(-)-CATECHINGALLATE

DRUGINFO

2-(2-((benzylamino)methyl)phenoxy)-5-chlorophenol

DRUGINFO

2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol

DRUGINFO

2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol

DRUGINFO

2-(2,4-dichlorophenoxy)-5-ethylphenol

DRUGINFO

2-(2,4-dichlorophenoxy)-5-isobutylphenol

DRUGINFO

2-(2,4-dichlorophenoxy)-5-isopentylphenol