TARGETID

T52522

FORMERID

TTDS00037

UNIPROID

ADRB2_HUMAN

TARGNAME

Adrenergic receptor beta-2 (ADRB2)

GENENAME

ADRB2

TARGTYPE

Successful target

SYNONYMS

Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Beta-2 adrenergic receptor; B2AR; ADRB2R

FUNCTION

The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.

PDBSTRUC

6MXT; 5X7D; 5JQH; 5D6L; 5D5B

BIOCLASS

GPCR rhodopsin

SEQUENCE

MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

DRUGINFO

Arformoterol

DRUGINFO

Bambuterol

DRUGINFO

Clenbuterol

DRUGINFO

Fenoterol

DRUGINFO

Formoterol

DRUGINFO

GW642444

DRUGINFO

Indacaterol

DRUGINFO

Isoetharine

DRUGINFO

Isoproterenol