TARGETID

T52297

FORMERID

TTDR00420

UNIPROID

NR1H3_HUMAN

TARGNAME

Oxysterols receptor LXR-alpha (NR1H3)

GENENAME

NR1H3

TARGTYPE

Patented-recorded target

SYNONYMS

Nuclear receptor subfamily 1 group H member 3; Nuclear receptor LXRalpha; Nuclear orphan receptor LXR-alpha; Liver X receptor alpha; LXRalpha; LXRA

FUNCTION

Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity.

PDBSTRUC

5HJS; 5AVL; 5AVI; 3IPU; 3IPS

BIOCLASS

Nuclear hormone receptor

SEQUENCE

MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

DRUGINFO

67S

DRUGINFO

BDBM50177012

DRUGINFO

BDBM50177019

DRUGINFO

US9006244, E1

DRUGINFO

US9006244, E2a

DRUGINFO

US9006244, E2b

DRUGINFO

US9073931, E1

DRUGINFO

US9073931, E2

DRUGINFO

US9073931, E3