TARGETID

T51487

FORMERID

TTDS00403

UNIPROID

GBRA1_HUMAN

TARGNAME

GABA(A) receptor alpha-1 (GABRA1)

GENENAME

GABRA1

TARGTYPE

Successful target

SYNONYMS

Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1

FUNCTION

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).

PDBSTRUC

6I53; 6D6U; 6D6T; 6D1S; 6CDU

BIOCLASS

Ligand-gated ion channel

SEQUENCE

MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ

DRUGINFO

Allopregnanolone

DRUGINFO

Amobarbital

DRUGINFO

Barbital

DRUGINFO

Barbiturate

DRUGINFO

Butabarbital

DRUGINFO

Butalbital

DRUGINFO

Butethal

DRUGINFO

Clobazam - Lundbeck

DRUGINFO

Ethanol