TARGETID

T51425

FORMERID

TTDNC00385

UNIPROID

VEGFC_HUMAN

TARGNAME

Vascular endothelial growth factor C (VEGFC)

GENENAME

VEGFC

TARGTYPE

Clinical trial target

SYNONYMS

Vascular endothelial growth factor-related protein; VRP; VEGF-C; Flt4-L; Flt4 ligand

FUNCTION

May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels.

PDBSTRUC

4BSK; 2X1X; 2X1W

BIOCLASS

Growth factor

SEQUENCE

MHLLGFFSVACSLLAAALLPGPREAPAAAAAFESGLDLSDAEPDAGEATAYASKDLEEQLRSVSSVDELMTVLYPEYWKMYKCQLRKGGWQHNREQANLNSRTEETIKFAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRRSLPATLPQCQAANKTCPTNYMWNNHICRCLAQEDFMFSSDAGDDSTDGFHDICGPNKELDEETCQCVCRAGLRPASCGPHKELDRNSCQCVCKNKLFPSQCGANREFDENTCQCVCKRTCPRNQPLNPGKCACECTESPQKCLLKGKKFHHQTCSCYRRPCTNRQKACEPGFSYSEEVCRCVPSYWKRPQMS

DRUGINFO

OPT-302

DRUGINFO

VGX-100

KEGGPATH

hsa04014:Ras signaling pathway

KEGGPATH

hsa04015:Rap1 signaling pathway

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04510:Focal adhesion

KEGGPATH

hsa04668:TNF signaling pathway

KEGGPATH

hsa05200:Pathways in cancer