TARGETID

T46456

FORMERID

TTDR01075

UNIPROID

RXRG_HUMAN

TARGNAME

Retinoic acid receptor RXR-gamma (RXRG)

GENENAME

RXRG

TARGTYPE

Successful target

SYNONYMS

Retinoid X receptor gamma; Nuclear receptor subfamily 2 group B member 3; NR2B3

FUNCTION

Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Receptor for retinoic acid.

PDBSTRUC

2GL8

BIOCLASS

Nuclear hormone receptor

SEQUENCE

MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT

DRUGINFO

Alitretinoin

DRUGINFO

Vitamin A

DRUGINFO

NRX-4204

DRUGINFO

9cUAB-30

DRUGINFO

IRX4204

DRUGINFO

SR-11237

DRUGINFO

AGN-34

DRUGINFO

LG100754

KEGGPATH

hsa03320:PPAR signaling pathway