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靶点信息73(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Glucocorticoid receptor (NR3C1)
TARGTYPE
Successful target
SYNONYMS
Nuclear receptor subfamily 3 group C member 1; GRL; GR
FUNCTION
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
PDBSTRUC
6EL9; 6EL7; 6EL6; 6DXK; 6CFN
BIOCLASS
Nuclear hormone receptor
SEQUENCE
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
DRUGINFO
Betamethasone Benzoate
DRUGINFO
Betamethasone Valerate
DRUGINFO
Dexamethasone sodium phosphate
DRUGINFO
Fluocinolone Acetonide
目标的 Wiki 路径数据
标题 | 内容 |
WP734 |
|
WP706 |
|
WP2882 |
|
WP2853 |
|
WP2840 |
|
WP236 |
|
WP1797 |
|
WP170 |
|
目标的蛋白质ID
标题 | 内容 |
TARGETID |
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UNIPROID |
|
TARGNAME |
|
TARGTYPE |
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目标的序列数据
标题 | 内容 |
Glucocorticoid receptor (NR3C1) |
|