TARGETID

T39977

FORMERID

TTDC00103

UNIPROID

MIF_HUMAN

TARGNAME

Macrophage migration inhibitory factor (MIF)

GENENAME

MIF

TARGTYPE

Clinical trial target

SYNONYMS

Phenylpyruvate tautomerase; MMIF; L-dopachrome tautomerase; L-dopachrome isomerase; Glycosylation-inhibiting factor; GLIF; GIF

FUNCTION

Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. Pro-inflammatory cytokine.

PDBSTRUC

6FVH; 6FVE; 6CBH; 6CBG; 6CBF

BIOCLASS

Intramolecular oxidoreductase

ECNUMBER

EC 5.3.2.1

SEQUENCE

MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA

DRUGINFO

3,4-Dihydroxycinnamic Acid

DRUGINFO

Anti-MIF antibodies

DRUGINFO

ISO-1

DRUGINFO

COR100140

DRUGINFO

4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME

DRUGINFO

4-hydroxyphenylpyruvic acid

DRUGINFO

6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE

DRUGINFO

AVP-13546