TARGETID

T37735

FORMERID

TTDI02082

UNIPROID

GLNA_HUMAN

TARGNAME

Glutamate decarboxylase (GLUL)

GENENAME

GLUL

TARGTYPE

Discontinued target

SYNONYMS

Glutamateammonia ligase

FUNCTION

Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia. Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ. Plays a role in ribosomal 40S subunit biogenesis. Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine.

PDBSTRUC

2QC8; 2OJW

BIOCLASS

Carbon-nitrogen ligase

ECNUMBER

EC 6.3.1.2

SEQUENCE

MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN

DRUGINFO

NLX-P101

KEGGPATH

hsa00250:Alanine, aspartate and glutamate metabolism

KEGGPATH

hsa00330:Arginine and proline metabolism

KEGGPATH

hsa00630:Glyoxylate and dicarboxylate metabolism

KEGGPATH

hsa00910:Nitrogen metabolism

KEGGPATH

hsa01100:Metabolic pathways

KEGGPATH

hsa01230:Biosynthesis of amino acids

KEGGPATH

hsa04724:Glutamatergic synapse